Jordi Surrallés

Inst. Reserca Hospital Sant Pau, Barcelona

Brief CV: Prof. Surrallés is currently the Scientific Director of Sant Pau Hospital Biomedical Research Institute, with over >1200 researchers and 70 research teams. He is also Director of the Joint Research Unit in Genomic Medicine UAB-Sant Pau, and Coordinating Director of the Master of Medical Genetics at the UAB, a join collaboration between Sant Pau and Vall Hebron UAB Hospitals. With a PhD in Genetics and postdoctoral experience in The Netherlands (Leiden University Medical Center) and Finland (Finnish Institute of Occupational Health), he originally set up his research team at the UAB where he is currently Full Professor of Genetics. He was member of the University Research Commission and Director of the UAB-Department of Genetics and Microbiology. In January 2017, he was appointed Director of the Genetics Department at Sant Pau Hospital, Barcelona. He is Director of the Biobank of DNA Repair Syndromes, Head of the Chromosome Fragility Laboratory Service and team leader at the Centre for Biomedical Network Research on Rare Diseases (CIBERER), where he acted as member of its Direction Board for 10 years (2007-2016).

He is specialist in the field of cancer predisposition syndromes due to mutations in DNA repair genes, where he has contributed with the discovery of novel causative genes in breast and colon cancer, Fanconi anemia, Bloom syndrome and others. Regarding therapeutic research, he holds two orphan drug designations by EMA, participates in academic clinical research including gene therapy clinical trials, and coordinates a trial on the prognostic value of genetic factors in Fanconi anemia and the first ever clinical trial on Fanconi anemia head and neck cancer. Thanks to his extensive research activity, he holds the ICREA-Academia award with four consecutive renewals (2008, 2013, 2018 and 2023).

Dr. Surrallés has supervised over 45 research grants as Principal Investigator awarded from public and private institutions world-wide including Catalan, Spanish, European, American and Australian institutions, adding up to >5M euros of competitive funding in the last 10 years. Prof. Surrallés is inventor of 5 patents, leads a number of contracts with private foundations and biotech-pharma companies including Moderna, Rocket, Roche, Boehringer Ingelheim, Genzyme, Merck and others. He has given tens of invited lectures in international meetings world-wide and published >130 publications including articles in Nature, Nature Communications, Nature Medicine, Cell Stem Cells, Blood, Gastroenterology, Am J Hum Genet, Genes and Dev and PNAS (>11.300 citations, H factor of 52).

He had supervised 20 PhD students and tens of Master Degree Students. He is reviewer of tens of scientific journals including Science, Nature, Molecular Cell Biology or Blood and Referee of multiple national and international funding agencies including European Research Council (EU), Agence Nationale de la Recherche-ANR (France), Agència de Gestió d’Ajuts Universitarisi de Recerca (AGAUR), ANEP (Ministerio de Ciencia y Tecnología), Cancer Research UK (UK), Commission of the European Union, Selection Board Subcommittee on Genetic Diseases and Cancer of the ISCIII (Spanish Ministry of Science and Innovation), Dutch Cancer Society (The Netherlands), Fanconi Cancer Fundation (USA), German-Israeli Fundation for Scientic Research and Development (Germany), INSERM (France), and the French National Cancer Institute (France).

Abstract: Fanconi anemia (FA) is a chromosome instability disorder characterized at the clinical level by malformations, progressive bone marrow failure and a high predisposition to leukemia, head and neck squamous cell carcinoma (HNSCC) and other tumors. FA cells show chromosome fragility and hypersensitivity to DNA interstrand cross-linking (ICL) mutagens due to deficiency in ICL repair. FA HNSCCs are therefore difficult to treat due to extreme toxicity of conventional genotoxic chemotherapies such as cisplatin. Extensive research is underway to genetically and functionally characterize FA tumors in search of therapeutic vulnerabilities. Therapeutic advances to induce cancer specific lethality based on a deep understanding of the genetics of FA and FA cancers will be shown with a focus on drug screening for the discovery and repurposing of afatinib from advanced lung cancer in the general population to head and neck cancer in Fanconi anemia patients.